NK cells positively influence the efficient rejection of BW-Sp3 T-cell lymphoma on subcutaneous injection.

Tumor cells (2 × 10⁶) were injected subcutaneously in the right flank of immunocompetent or anti-ASGM-1–treated AKR mice, and tumor diameter was measured in function of time. Results are represented as the mean tumor diameters (± SEM) of immunocompetent mice with regressing BW-Sp3 tumors (▪, 2 of 6 mice), immunocompetent mice with progressing BW-Sp3 tumors (♦, 4 of 6 mice), or NK-depleted mice with progressing tumors (●, 6 of 6 mice). *Indicates the time point at which 50% of the α-ASGM-1–depleted hosts prematurely succumbed to the tumor load.