Platelets from Vav1-deficient mice have an impaired aggregation response.

Platelets from wild-type and Vav1^−/− mice were stimulated with the indicated concentrations of CRP (i-iii) or thrombin (iv-vi) in the absence of inhibitors of secondary mediators or EGTA. The change in optical density indicative of aggregation was monitored. One experiment representative of 3 is depicted.