F-actin polymerization is normal in Vav1-deficient platelets.

The F-actin content of basal platelets or platelets stimulated with CRP (10 μg/mL, 45 seconds) or thrombin (1 U/mL, 30 seconds) from wild-type and Vav1^−/− mice were measured by FACS as described in “Materials and methods.” Data are presented as the increase in mean fluorescence over basal as a percentage of wild type, plus the standard error of the mean. One experiment representative of 3 is depicted.