Risk stratification by application of a 2-biomarker MAGIC algorithm at the onset of GVHD. Six-month cumulative incidence of NRM in Ann Arbor risk groups AA1, AA2, and AA3 as defined by the MAGIC algorithm and applied to serum samples obtained at the onset of GVHD symptoms (n = 212): AA3: 46% (95% confidence interval, 32-58); AA2: 24% (95% confidence interval, 14-36); and AA1: 8% (95% confidence interval, 4-15). The proportions of patients in each risk group, as represented by the bar graph, were AA3: 27% (n = 57); AA2: 28% (n = 59); and AA1: 45% (n = 96). Adapted from Hartwell et al⁴⁸  with permission.