Histologic changes of liver GVHD.

Characteristic histology of classical liver GVHD with bile duct lymphocytic infiltrates and injury. (A) Portal lymphocytic inflammation is also present. (B) Lobules show mild hemosiderin accumulation with no significant inflammation. (C) Hepatitic-variant liver GVHD demonstrates only mild chronic inflammation of the portal tracts, with minimal bile duct changes. (D) In contrast, the lobules show definite hepatitis. Original magnification × 25; hemotoxylene-eosine staining.