Fig. 6.
Fig. 6. Genetic interaction of NUP98-HOXA9 orHOXA9 with BCR-ABL to transform mouse BM cells. / The proportion of doubly transduced (ie, G418-resistant and EGFP-expressing) colony-forming cells (CFCs) increased from between 10% and 16% at the time of transplantation to between 46% and 67% at the time leukemia occurred in primary recipients. The selector gene was neor forNUP98-HOXA9 or HOXA9 provirus (Figure 1A) and EGFP for BCR-ABL (n = 3 mice for NUP98-HOXA9plus BCR-ABL; n = 2 mice for HOXA9plus BCR-ABL). At least 30 colonies were examined per mouse. Untransduced BM cells failed to grow in the presence of G418.

Genetic interaction of NUP98-HOXA9 orHOXA9 with BCR-ABL to transform mouse BM cells.

The proportion of doubly transduced (ie, G418-resistant and EGFP-expressing) colony-forming cells (CFCs) increased from between 10% and 16% at the time of transplantation to between 46% and 67% at the time leukemia occurred in primary recipients. The selector gene was neor forNUP98-HOXA9 or HOXA9 provirus (Figure 1A) and EGFP for BCR-ABL (n = 3 mice for NUP98-HOXA9plus BCR-ABL; n = 2 mice for HOXA9plus BCR-ABL). At least 30 colonies were examined per mouse. Untransduced BM cells failed to grow in the presence of G418.

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