TPO improves regeneration of bone marrow progenitors.

Mice receiving TBI with 6 Gy were treated with TPO 2 hours and 24 hours after irradiation. After 7 days, GM-CFUs (GM), BFU-Es (E), and Meg-CFCs (Meg) were measured per femur. Regeneration of bone marrow progenitors improved with the 2-hour but not the 24-hour post-TBI administration of TPO. Reprinted from Neelis et al144 with permission.