Fig. 6.
KLH-specific T-cell proliferation after gene transfer.
After subcutaneous immunization with KLH, the lymph nodes draining the immunization site of RAG-2–transduced mice or C57BL/6 mice were cultured in the presence of increasing antigen concentrations (0, 0.125, 0.4, 2, 10, 50 ng/mL). Proliferation was measured after addition of [3H]-thymidine. Values are expressed as the means ± SD obtained in 4 RAG-2–transduced mice and 2 C57BL/6 mice.