Proposed impacts of fur expression/regulation in megakaryocytes.

The events depicted here are initiated with hematopoietic cell differentiation into megakaryocytes. In this scheme, we extrapolate the results observed with various megakaryocytic cell lines to the events proposed to occur in primary cells. Fur regulation in megakaryocytes is, in part, under the control of the transcription factor GATA-1, and the relevance of other transcription factors in this regulation is not excluded. The role of furin in the maturation/activation of the integrin α_IIb will be published elsewhere (M.-H. L. et al, mansucript in prepration).