Bak conformational changes in drug-induced apoptosis of CLL cells.

(A) Dot plots of Bak conformational changes in cells from one representative patient following incubation with medium alone, 5 μg/mL fludarabine, 10 μM dexamethasone, or the FCM combination for 24 hours. The percentage of Baκ-positive cells is indicated in each panel. (B) Correlation between cell viability and Bak-positive cells following incubation of cells from 10 patients with medium alone, fludarabine, dexamethasone, or the FCM combination. (C) Correlation of Bax and Baκ-positive cells following incubation of cells from 10 patients with medium alone, fludarabine, dexamethasone, or the FCM combination for 24 hours.