Fig. 1.
Effect of α-defensin on contraction of aortic rings.
(A) The effect of increasing concentrations of α-defensin on the contraction of denuded rat aortic rings (▴). The effect of increasing concentrations of PE was measured in the absence (■) or presence (▪) of 1 μM α-defensin. (B) The effect of anti–α-defensin antibodies: EC50 of PE was determined in the absence (Cont) or presence of 1 μM α-defensin (Def), α-defensin and specific anti–α-defensin antibody (Def+sAb), or α-defensin and irrelevant antibodies (Def+irAb). All experiments, unless otherwise indicated, were performed in triplicate and were repeated at least 3 times. In this and in all graphs, the data are presented as means ± SD of 3 experiments.
