Fig. 9.
Fig. 9. Putative secondary structure of the CD43promoter. / Misalignment of direct repeats of the sequence GGTGG may form slippage structures at the 5′ end of the promoter. The single-stranded region on the sense strand of these structures would support efficient binding of Purα. Two types of slippage structures are possible. One is illustrated. Pairing of an inverted repeat of the sequence CAGGGCCC could form a cruciform structure immediately downstream of the slippage structures. This possible cruciform is illustrated. The single-stranded loop region on the sense strand of the cruciform would support efficient binding of hnRNP-K. The DNA equivalent of the consensus RNA binding site of hnRNP-K is marked by bold characters.66 The nucleotides defined by mutation analysis as being critical for hnRNP-K binding are marked with arrowheads.56 The 2 major transcription initiation sites of the CD43 gene are marked with asterisks.55

Putative secondary structure of the CD43promoter.

Misalignment of direct repeats of the sequence GGTGG may form slippage structures at the 5′ end of the promoter. The single-stranded region on the sense strand of these structures would support efficient binding of Purα. Two types of slippage structures are possible. One is illustrated. Pairing of an inverted repeat of the sequence CAGGGCCC could form a cruciform structure immediately downstream of the slippage structures. This possible cruciform is illustrated. The single-stranded loop region on the sense strand of the cruciform would support efficient binding of hnRNP-K. The DNA equivalent of the consensus RNA binding site of hnRNP-K is marked by bold characters.66 The nucleotides defined by mutation analysis as being critical for hnRNP-K binding are marked with arrowheads.56 The 2 major transcription initiation sites of the CD43 gene are marked with asterisks.55 

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