Increased hepatic nonheme iron concentration in mice lacking classical MHC class I molecules.

Liver samples from B6, H2K^b−/−,H2D^b−/−,H2K^b−/−D^b−/−,CD8^−/−, and Rag2^−/−male mice aged 4 to 5 months were analyzed for nonheme iron concentration. Individual values are represented. n indicates the number of mice analyzed; the mean and the standard deviation (SD) values are indicated. P values were calculated by the unpaired Student 2-tailed t test; values ofP < .05 were considered significant. As indicated, mean values from H2K^b−/−,H2D^b−/−, andH2K^b−/−D^b−/− mice were significantly different from B6 control mice; not indicated, but also significantly different (P < .05), were the mean values for these groups: H2K^b−/− versusH2K^b−/−D^b−/−;H2K^b−/− versusCD8^−/−; H2K^b−/−versus Rag2^−/−;H2D^b−/− versusCD8^−/−; H2D^b−/−versus Rag2^−/−;H2K^b−/−D^b−/− versusCD8^−/−; andH2K^b−/−D^b−/− versusRag2^−/−.