American Society of Hematology

Fig. 1.

$Fig. 1. Distinct CDR3 size distributions in CD4+ and CD8+ naive and memory T-cell subsets. / (A) Different CDR3 size fragments identified in CD4+ (top lane) and CD8+ (bottom lane) T-cell subsets. Representative example of Vβ3, Vβ5.1, and Vβ13 families in the sorted subfractions of a patient with acute lymphoid leukemia (UPN 442) on day 147 after transplantation. (B) Increase in the median number of bands per Vβ family in naive and memory CD4+ and CD8+ T-cell subsets after transplantation. Before day 200, no naive-type T cells were available for analysis. In parallel with the appearance of naive-type T cells in the periphery, the mean number of bands per Vβ family of the CD4+ and CD8+memory compartment significantly increased between the study time points, days 101 to 200 and days 201 to 300 (P < .001, Mann-Whitney U test).$

Distinct CDR3 size distributions in CD4⁺ and CD8⁺ naive and memory T-cell subsets.

(A) Different CDR3 size fragments identified in CD4⁺ (top lane) and CD8⁺ (bottom lane) T-cell subsets. Representative example of Vβ3, Vβ5.1, and Vβ13 families in the sorted subfractions of a patient with acute lymphoid leukemia (UPN 442) on day 147 after transplantation. (B) Increase in the median number of bands per Vβ family in naive and memory CD4⁺ and CD8⁺ T-cell subsets after transplantation. Before day 200, no naive-type T cells were available for analysis. In parallel with the appearance of naive-type T cells in the periphery, the mean number of bands per Vβ family of the CD4⁺ and CD8⁺memory compartment significantly increased between the study time points, days 101 to 200 and days 201 to 300 (P < .001, Mann-Whitney U test).

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