Effects of Mpl ligand on platelet and megakaryocyte levels and structure in the BclxL transgenic and control mice.

(A) Level of circulating platelets on day 5 after a single injection of PEG-rmMGDF (50 μg/kg) in the peripheral blood of WT and Tg19 mice. Numbers are averages ± SD for 3 different mice. (B) Number of acetylcholinesterase-positive cells in mouse BM after injection of PEG-rmMGDF (50 μg/kg). The numbers are averages ± SD for 2 mice, each with 3 determinations. Details are as in the legend for Figure 3. (C) Transmission electron micrograph of megakaryocytes from WT and Tg19 mice after PEG-rmMGDF injection. Original magnification, × 16 000 in the top panel and × 6800 in the lower panel.