Fig. 2.
NK cells recovered from SCID mice treated with an Ab against the IL-2/15Rβ chain or control Ab.
SCID mice (3 per group) were treated twice daily (500 μg/dose) with the Fab fragment of a blocking Ab against the IL-2/15Rβ chain (TM-β1) or control Fab (rat IgG). Shown is a flow histogram gated on splenic lymphocytes and stained for DX5-PE after 7 days of treatment with control Fab (A) or anti–IL-2/15Rβ Fab (B). Results from 2 representative animals are shown. (C) Significantly fewer splenic NK cells were recovered from mice treated with anti–IL-2/15Rβ than from controls (38.2 ± 3.8 × 103 versus 372.1 ± 28.2 × 103 NK cells/spleen). The asterisk indicates P less than .0004. Error bars indicate SEM.
