Recurrent somatic mutations in MDS by pathway. Includes approximate frequency of the most common recurrent somatic mutations in MDS and their prognostic significance. Some mutations influence the phenotype and are therefore more common in specific subtypes of MDS; for instance, SF3B1 mutations are found in up to 80% of patients with MDS-RS and SRSF2 mutations are more common in MPN/MDS overlap syndromes such as chronic myelomonocytic leukemia. Mutation frequencies and their prognostic significance are adapted from Bejar et al,³²  Haferlach et al,⁵  and Papaemmanuil et al⁶  published frequencies. The negative prognostic impact with SRSF2 mutations is adapted from Thol et al.⁶³