Fig. 2.
Platelet adhesion on stimulated endothelial cells.
Washed normal platelets were perfused at a constant shear stress of 2.5 dyne/cm2 over a monolayer of HUVECs. (A) Long lines of platelets aligned as “beads on a string” above histamine-stimulated (i), but not unstimulated (ii), HUVECs. Original magnification × 400. (B) Platelet strings repeatedly stretch and relax in the fluid stream. (C) The length of strings varied but could be several millimeters long (bar = 100 μm). The figure is representative of 86 separate experiments using HUVECs and platelets from 34 different donors.
