T-cell repertoire diversity in healthy subjects.

Three representative example of spectratype analyses performed on 13 healthy control subjects show that most TCR-Vβ families exhibit a diverse, gaussian distribution of CDR3 lengths. However, some TCR-Vβ families do exhibit a skewed or restricted distribution of CDR3 lengths. The ages of the control subjects are (A) 31, (B) 41, and (C) 61 years.