SDF expression significantly reduces the in vivo tumorigenicity of tumor cells.
(A) C57BL/6 mice (10 mice/group) were injected intravenously with the indicated numbers of live SDF-C1498 cells or control C1498 cells. Mice injected with 1 × 106 SDF-C1498 (●) had some tumor growth delay as compared to control (▪) mice (P < .005), but eventually developed lethal leukemia, whereas 90% of the mice injected with 2 × 105 SDF-c1498 cells (▴) rejected their leukemia. This graph is representative of 4 independent experiments. (B) C57BL/6 mice (10 mice/group) were injected intradermally in the flank with control B16F1 (▪) or SDF-B16F1 (▴) cells. All control mice developed lethal tumors; 50% of the SDF-B16F1 mice remained tumor free (P = .0014). This graph is representative of 3 independent experiments.
