Scid mice do not reject SDF-tumors.
(A) C57BL/6 scidmice (10 mice/group) were injected intravenously with 2 × 105 control C1498 (▪) or SDF-C1498 (✖) cells. Naive C57BL/6 mice injected with 2 × 105 control C1498 (●) or SDF-C1498 (▴) cells were used as control. Naive mice injected with SDF-C1498 cells rejected their tumor; all other groups of mice developed lethal leukemia. The results are representative of 2 separate experiments. (B) C57BL/6 scid mice (10 mice/group) were injected intradermally with 105 control B16F1 (▪) or SDF-B16F1 (●) cells. Control naive C57BL/6 mice were injected with 105 SDF-B16F1 (▴) cells. Forty percent of naive animals rejected SDF-B16F1 tumors and remained tumor-free. Both groups ofscid animals developed lethal tumors. Similar results were obtained in a second experiment.
