Reduced numbers of total and factor-independent LTC-IC–derived CFCs from BCR-ABL–transduced IL-3^−/− vs +/+ lin⁻GFP⁺ cells.

The numbers of LTC-IC–derived CFU-GMs (left panel), erythroid burst-forming units (BFU-Es; middle panel), and CFU-granulocyte/erythroid/macrophage/megakaryocytes (GEMMs) (right panel) able to make colonies in the presence of SF, IL-6, and EPO (▪) or without any added growth factors (□) are shown for the various combinations of target cells and viruses indicated. Values shown are the means ± SEM from 3 experiments each with MIG-, BCR-ABL– and BCR-ABL plus IL-3–transduced +/+ and IL-3^−/− cells.