Fig. 3.
P38-and Erk-MAPK as well as p70S6 kinase are not involved in spontaneous apoptosis of B-CLL cells.
Cells (1 × 106 cells/mL) were incubated with increasing amounts of SB203580, a specific inhibitor of p38-MAPK (A), PD98059, which inhibits Erk-MAPK pathway (B), or rapamycin, which blocks p70S6 kinase (C). Apoptosis was measured by annexin/PI staining after incubation for 24 hours. One representative result of 10 individual experiments is shown.
