Fig. 5.
Fig. 5. Modulation of proapoptotic and antiapoptotic proteins in response to PI-3K inhibition. / Representative immunoblot data show regulation of proapoptotic and antiapoptotic proteins. B-CLL cells were cultured with or without 10 μM LY294002. Cells were harvested after 12 and 24 hours and whole cell lysates were prepared. A protein content of 40 μg was subjected to SDS-PAGE/immunoblot analysis by the use of specific antibodies for Bax, Bcl-2, XIAP, Mcl-1, and caspase-3.

Modulation of proapoptotic and antiapoptotic proteins in response to PI-3K inhibition.

Representative immunoblot data show regulation of proapoptotic and antiapoptotic proteins. B-CLL cells were cultured with or without 10 μM LY294002. Cells were harvested after 12 and 24 hours and whole cell lysates were prepared. A protein content of 40 μg was subjected to SDS-PAGE/immunoblot analysis by the use of specific antibodies for Bax, Bcl-2, XIAP, Mcl-1, and caspase-3.

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