Fig. 4.
Effect of compstatin on complement activation.
Activation products from the classical (C1rs-C1inh complexes), alternative (C3bBbP), final common (C3bc), and terminal (C5a and TCC) pathways were measured in plasma from the same whole blood experiments as described in Figure 3. T0 indicates baseline sample; T10, sample incubated for 10 minutes after addition of PBS. E coli samples (2 × 107 bacteria per milliliter) were incubated for 10 minutes after preincubation with equal volumes of PBS (P), 200 μM compstatin (C), or 200 μM control peptide (CP). Median and range of the 6 experiments are indicated. AU indicates arbitrary units.
