Fig. 7.
![Fig. 7. Effect of the C5aR antagonist AcF[OPdChaWR] on. / E coli–induced oxidative burst in granulocytes.The left panel shows dose-response effect of the C5aR antagonist using 1 × 108 E coli per milliliter (1 representative of 5 experiments is shown). The right panel shows the effect of 2 μM C5aR antagonist on E coli–induced oxidative burst by reducing the concentration ofE coli (median and range of triplicate). The oxidative burst is given as median fluorescence intensity (MFI). ▵ indicates baseline value (T0); ▴, whole blood incubated 10 minutes withE coli (1 × 108 bacteria per milliliter); ●, E coli plus C5aR antagonist; ○, E coli plus control peptide; and ■, E coli plus PBS.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/100/5/10.1182_blood.v100.5.1869.h81702001869_1869_1877/3/h81723034007.jpeg?Expires=1735545777&Signature=eAsaRBnM2l4x4W9wqYP69BNvHs0aZx~YC9qnJveSKuvaRkvHfdtoMO8-DHTUBf4qJ2uHMV~lpCrJCcNtnlcXrFHYq9RMYPOrKmKJvt6au-Yph93rx8PlQwEkGa9Di9bIlTwEeMIq8-yYrmXdTTd7-GhZ4o0zMVsjH7lHPQxQLHi~VJL3ThLerMucnGZ5qTYU0uSkUmKls~yXrJ~wwDfCgh3WKDCEaI0-fc89fRPVLJrSxc1oaAW7ONbIfVIAj~-ONwjhrWGQjv0HV9IsGzDM54EWZ0lGAhhI-IPgXURq7LDjHs7JVOidu~01SFY8iohvkUJjBQX3gw1yc2LXLCuX1A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of the C5aR antagonist AcF[OPdChaWR] on
E coli–induced oxidative burst in granulocytes.The left panel shows dose-response effect of the C5aR antagonist using 1 × 108E coli per milliliter (1 representative of 5 experiments is shown). The right panel shows the effect of 2 μM C5aR antagonist on E coli–induced oxidative burst by reducing the concentration ofE coli (median and range of triplicate). The oxidative burst is given as median fluorescence intensity (MFI). ▵ indicates baseline value (T0); ▴, whole blood incubated 10 minutes withE coli (1 × 108 bacteria per milliliter); ●, E coli plus C5aR antagonist; ○, E coli plus control peptide; and ■, E coli plus PBS.
