Fig. 9.
Effect of C5aR antagonist on phagocytosis.
The C5aR antagonist dose dependently inhibited granulocyte (left) and monocyte (right) phagocytosis of E coli. Phagocytosis was completely abolished at 10 μM C5aR antagonist, whereas control peptide had no effect. One representative of 5 experiments is shown. ▵ indicates baseline value (T0); ▴, whole blood incubated 20 minutes with E coli (1 × 108 bacteria per milliliter); ●, E coli plus C5aR antagonist; and ○,E coli plus control peptide.
