Fig. 3.
Bay 11-7082 reduces cell growth and induces apoptosis of HTLV-I–infected T-cell lines.
Various T-cell lines were placed in culture at 1 × 105 cells/mL without or with Bay 11-7082 for 48 hours. (A) Cell growth was assessed by the WST-1 method, is expressed as percentage of control (untreated cells), and represents the mean of 3 independent experiments. (B) Induction of apoptosis of HTLV-I–infected T-cell lines following inhibition of NF-κB. 1 × 106 cells were labeled with phycoerythrin-conjugated Apo2.7 and analyzed by flow cytometry. Data represent the mean ± SD percentages of apoptotic cells from 3 independent experiments for both untreated cells (open bars) and cells treated with 5 μM Bay 11-7082 (solid bars).
