Effect of EpoR on recovery from anemia.

Anemia was induced in 4 different EpoR genotypes of mice by withdrawing blood from the retro-orbital venous plexus every day for 4 days (day 1 to 4). Recovery from anemia was observed over a period of 1 week. (A) Peripheral blood indices of the 4 lines of mice under normal (day 1) and anemic (day 4) conditions are shown in each panel. Hb, MCV, RBC, WBC, and PLT are shown. HCT values (B) and Epo concentrations in the plasma (C) were measured daily. Results are shown with SD; n = 5 for each line. * indicates P < .01; +,P < .05 compared with wild-type mouse.