Fig. 1.
Time course of coagulation factors during warfarin therapy.
The concentration of coagulation factors II (⋄), VII (▵), IX (♦), and X (×), and prothrombin time (○), and APTT (●) during initiation of warfarin treatment (A; “0 days” is at the start of treatment), and during one year of stable treatment (B; “0 days” is simply at the start of this period) in a patient with FIX propeptide mutation. The activity of the various coagulation factors and the prothrombin time are described as a fraction of 1.0; ie, 1.0 = 100%.