Human IL-17E transgenic lymph nodes revealed lymphadenopathy.

Histologic sections of nontransgenic control littermates (left panels) and transgenic (right panels) mesenteric lymph nodes. Panels A, B, G, and H are stained with hematoxylin and eosin; panels C and D, B220-stained sections; E and F, mouse IgG1-stained sections. All panels illustrate markedly enlarged transgenic lymph nodes disrupted of their normal architecture by the infiltration of eosinophils (B, asterisk; H, arrows), B220⁺ B lymphocytes (D), and mouse IgG1⁺ plasma cells (F) as compared to the nontransgenic controls. Panel H also illustrates that transgenic lymph nodes had a substantial infiltration of multinucleated inflammatory giant cells (arrowheads). Magnification of × 2 or × 40 as indicated.