Splenomegaly and bone marrow myeloid hyperplasia in the hIL-17E transgenic mice.

Transgenic spleen (B,D) and bone marrow (F) illustrate B220⁺ lymphoid hyperplasia (arrows) and marked eosinophilic myeloid hyperplasia, respectively, compared to the nontransgenic controls (A,C,E). The transgenic spleen also exhibited eosinophilic hyperplasia in the red pulp (D). Tissues are stained with hematoxylin and eosin (H&E) or B220 as indicated; magnification of × 2 or × 40 as indicated.