Effect of DLI at 3 and 12 weeks on survival after leukemic challenge.
Chimeras given DLI at 3 or 12 weeks and age-matched chimeras not given DLI were inoculated with 5 × 106 BW5147.3 leukemia cells at week 4 and 13, respectively. As a control, untreated host-type AKR mice were given the same leukemia challenge. Kaplan-Meier survival curve is shown of a total of 20 (DLI) and 18 (no DLI) week 12 chimeras, a total of 14 (DLI) and 13 (no DLI) week 3 chimeras, and a total of 14 untreated AKR control mice. Results are shown from 4 similarly designed experiments: all groups were tested together in 2 experiments, week 12 chimeras were tested in 2 additional experiments (n = 4-7/group). *P < .05 for comparison between DLI week 3 and all other groups, and **P < .05 for comparison between co AKR and all other groups, as tested by the log-rank test.
