γ Globin expression in baboons treated with SCFADs.
(A) Percentage F-reticulocytes in baboons treated with phenoxyacetic acid, administered intravenously once daily at 900 mg/kg for 2 doses and 1100 mg/kg for 1 dose in baboon 225 (○) and at 500 mg/kg per dose daily for 5 days in baboon 1392 (●). (B) F-reticulocytes in baboons treated with 2, 2 dimethyl butyrate are shown. F-reticulocytes were induced by 2 oral doses of 500 and then of 700 mg/kg, every other day, in a dose-escalation safety study in baboon 1392 (▴); 200 mg/kg per dose intravenously 5 days a week in baboon 1997 (▪); 500 mg/kg orally administered every other day over 2 weeks to baboon 894 (●); and 150 mg/kg intravenously once daily for 5 days in baboon 2063 (○). (C) F-reticulocytes in baboons treated with α methyl hydrocinnamic acid administered orally at 500 mg/kg for 2 doses every other day and 700 mg/kg once in a dose-escalation safety study in baboon 994 (●), at 200 mg/kg IV once daily for 5 days to baboon 1593 (▴), at 200 mg/kg intravenously once daily for 5 days to baboon 1997 (■), and at 150 mg/kg intravenously once daily for 5 days in baboon 2063 (▪). (D) Globin chain synthesis in a baboon (1573) that under phlebotomy before (i) and after (ii) treatment with α methyl hydrocinnamic acid. Closed symbols designate 3H cpm, and open symbols designate OD 280. The proportion of γ globin synthesis (γ/γ + β × 100) is shown.
