Pharmacokinetic analyses of 2 additional SCFADs in baboons.

(A) Pharmacokinetic analyses of the SCFAD 3-(3,4 dimethoxyphenyl)-propionic acid in 2 baboons. Plasma levels are shown after single doses of 50 mg/kg intravenously (○), 50 mg/kg orally (●) in baboon 1197, 150 mg/kg intravenously (■) and orally (▪) in baboon 1997, and 200 mg/kg orally in baboon 1997 (▴). (B) Pharmacokinetic analyses of the SCFAD 4-(3,4 dimethoxyphenyl) butyric acid after the administration of single low oral doses in 3 baboons. Plasma levels are shown after oral doses of 20 mg/kg in baboon 1997 (■) and baboon 3397 (▪), after 40 mg/kg in baboon 3397 (▵), and after 50 mg/kg given on 2 separate occasions in baboon 5014 (○ and ●).