Enhancement of chimerism in a mixed chimera created by IUHSCT is equivalent to that observed in naive congenic recipients.

Direct comparison of chimerism levels following TBI and BMT in allogeneic chimeras created by IUHSCT with those following congenic transplantation of a naive host (A) keeping the recipient strain constant (SJL→B6 and B6Ly5.2→B6) or (C) keeping the donor strain constant (B6→Balb/c and B6→B6Ly5.2). Analysis of multilineage engraftment in these strain combinations was performed at 24 weeks after transplantation (B). For all graphs, P < .05 when comparing congenic to allogeneic strain combination chimerism levels and multilineage engraftment levels unless indicated by an asterisk.