Outcomes in AML modified by clinical, cytogenetic, and molecular features as well as therapy. This volcano plot shows the relative contribution to prognosis (expressed as the logarithmic hazard on the x-axis; positive values indicate a worsening effect) vs P values (expressed on an inverted logarithmic scale on the y-axis) for each of 228 variables included in their random-effects model. Circles above the dotted line represent 18 variables with a q value of <0.1; the size of each circle corresponds to the frequency of the variable, as indicated in the box. The incremental contribution of age is shown for every 10 years of age, and the incremental contribution of the white blood cell count (WBC) is shown for each increase of 1 × 109 cells/L. Colors correspond to clinical variables (red), gene-gene interactions (light blue), copy number variations (green), treatment effect (orange), demographics (pink), and fusion genes (purple). Data reprinted with permission.¹²