Analysis of the somatic mutations in the immunoglobulin V_Hgenes of 22 CLL patients.

The distribution of replacement (▴) and silent (*) mutations in the complementarity determining regions (CDRs) and framework regions (FWs) of each heavy chain are indicated. Listed on the left margin are the designations for the heavy chain of each CLL sample. Indicated on the right margin are the V_H genes, known D segments, and J_H genes that have the highest homology with each heavy-chain cDNA sequence.