Fig. 4.
Increase in signal intensity of tyrosine phosphoproteins of 70 to 72 kDa following BCR ligation.
Each symbol represents one CLL sample. The height of each symbol corresponds to the percentage increase in phosphoprotein signal intensity caused by BCR ligation, as indicated on the left-hand axis. The graph on the left segregates the symbols of leukemia cell samples that did (ZAP-70+) or did not (ZAP-70−) express ZAP-70, whereas the graph on the right segregates samples on the basis of whether they expressed ZAP-70 and CD38 (ZAP-70+/CD38+, left group); ZAP-70 without CD38 (ZAP-70+/CD38−, middle group); or neither ZAP-70 nor CD38 (ZAP-70−/CD38−, right group). The horizontal line drawn among the symbols of each group represents the average fold-increase in signal intensity for that group.