Effect of Delta4 expression on blood cell formation.

Delta4 expression alters blood cell formation. WBC (panels A,B), hemoglobin, hematocrit (panel B), and platelet (panels B,C) levels in mice transplanted with bone marrow cells infected with the control viruses or the viruses carrying Delta 4. These data (mean values ± SE) resulted from independent experiments using the pMSCVpac or the MigR viruses. Inset: the ratio, in early time points after transplantation, between the WBC levels in control mice and in mice transduced with Delta 4 is shown. In panel B, differential blood cells counts, platelets, and hemoglobin and hematocrit levels were determined 15 weeks after BMT from mice transduced with control viruses (MSCVpac, n = 4; MigR, n = 2) or Delta4 viruses (MSCVpacDelta4, n = 2; MigRDelta4, n = 2). The cell number per microliter is indicated. Multiplication factors differ for different cell types and are shown in brackets. Hemoglobin and hematocrit are shown as grams per deciliter and percentages, respectively.