Plasma 7E3 pharmacokinetics following IVIG treatment.

Rats (3-4/group) were dosed intravenously with IVIG (0-2 g/kg) followed by 7E3 (8 mg/kg). (A) Plasma 7E3 pharmacokinetic data for each animal given saline (i), 0.4 g/kg IVIG (ii), 1 g/kg IVIG (iii), or 2 g/kg IVIG (iv). (B) Average plasma pharmacokinetic data for animals receiving 7E3 and IVIG. Treatment groups are designated as follows: saline (●), 0.4 g/kg (▪), 1 g/kg (▴), and 2 g/kg (♦). 7E3 concentrations were determined via ELISA. Error bars represent the SD about the mean concentration at each time point. IVIG treatment significantly increased the clearance of 7E3 (P < .001), calculated from the concentration versus time profiles shown in this figure.