American Society of Hematology

Fig. 4.

$Fig. 4. Killing of lymphoma cells by chimeric antibodies. / Lysis of ARH-77 lymphoma cells was measured in 3-hour 51Cr release assays, using 1 μg/mL of the indicated chimeric isotypes of HLA class II antibody F3.3. Unseparated blood (whole blood) served as effector source, which was then fractionated into polymorphonuclear (PMN) or mononuclear (MNC) effector cells or into complement-containing plasma to identify effector mechanisms of chimeric antibodies. Isolated PMNs or MNCs were used at an effector-to-target-cell ratio of 40:1. Data are presented as mean percentage specific lysis ± SEM from at least 4 independent experiments. Significant (P < .05) antibody-mediated lysis is marked by an asterisk (*).$

Killing of lymphoma cells by chimeric antibodies.

Lysis of ARH-77 lymphoma cells was measured in 3-hour ⁵¹Cr release assays, using 1 μg/mL of the indicated chimeric isotypes of HLA class II antibody F3.3. Unseparated blood (whole blood) served as effector source, which was then fractionated into polymorphonuclear (PMN) or mononuclear (MNC) effector cells or into complement-containing plasma to identify effector mechanisms of chimeric antibodies. Isolated PMNs or MNCs were used at an effector-to-target-cell ratio of 40:1. Data are presented as mean percentage specific lysis ± SEM from at least 4 independent experiments. Significant (P < .05) antibody-mediated lysis is marked by an asterisk (*).

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