Influence of E/T ratio and antibody concentration on IgA-mediated ADCC.

IgA1-, IgA2-, or IgG1-mediated killing of Raji Burkitt lymphoma cells was investigated using different E/T ratios (A) or antibody concentrations (B). Antibody concentration in panel A was 1 μg/mL; E/T ratio in panel B was 40:1. Data are presented as mean percentage specific lysis ± SEM observed with isolated PMNs from at least 3 different donors. Significant killing (P < .05) is indicated by an asterisk (*).