Fig. 4.
![Fig. 4. CML-DCs are defective in presentation at suboptimal dose of peptide. / DCs were generated from healthy individuals (○) and from CML patients (●): patient 1 (A-C) and patient 2 (D-F). Immature HLA-DR7–expressing DCs were pulsed overnight with 3 different doses of peptide HA307-319 (1 μg/mL [A,D]; 0.1 μg/mL [B,E]; 0.01 μg/mL [C,F]). Different numbers of irradiated and prepulsed DCs were cultured in the presence of HA307-319–specific T-cell clone (7P24). The data are expressed as counts per minute (cpm) ± standard deviations (SD). Data are representative of 5 experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/101/9/10.1182_blood-2002-06-1841/4/h80934217004.jpeg?Expires=1735562424&Signature=IgQUU8UL1zHcAn6JJHpeLm0tA~inbR-ffxbAXhiXFErQENzV5w~I-ANh3P9bUG0TwQpFgHiXabJD9FUF5gihim4Wz2LTJg2nvTSmS65FtMPSREYDIqJKT7aqnRlnXlYjberSINw441nFQHtkx4ip-6uiJByE8P5rDTdVsTMdxHyNR1S0bHG70ao36LbYrm7Jw~VvvpH-A1cYMYrXqgu-dBhNGZHxxhJI8NN95IqvsHRSK9q5Zrug1pWsr9jlCB-HCzRDtTC5Kf6Tjr17f~BcSZLJQomEalvqedVIQF0Z9~DH1-tWTnNvuVxRclWsqtFukaegG9BeVikGDux7XiMPmg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CML-DCs are defective in presentation at suboptimal dose of peptide.
DCs were generated from healthy individuals (○) and from CML patients (●): patient 1 (A-C) and patient 2 (D-F). Immature HLA-DR7–expressing DCs were pulsed overnight with 3 different doses of peptide HA307-319 (1 μg/mL [A,D]; 0.1 μg/mL [B,E]; 0.01 μg/mL [C,F]). Different numbers of irradiated and prepulsed DCs were cultured in the presence of HA307-319–specific T-cell clone (7P24). The data are expressed as counts per minute (cpm) ± standard deviations (SD). Data are representative of 5 experiments.
