CML-DCs are defective in antigen capture.

DCs were generated from healthy individuals (○) and from CML patients (●): patient 6 (A-B), patient 1 (C-D), and patient 15 (E-F). Immature DCs were incubated with either FITC-DX (A,C,E) or with LY (B,D,F), and the mean fluorescence intensity (MFI) was evaluated at different time points, as indicated. The results are representative of 15 experiments obtained with DCs derived from different patients as indicated in Table 1.