Figure 1.
Figure 1. CAR structure, according to signaling domains. CAR molecules link scFv to intracellular signaling domains. The intracellular component includes the CD3ζ alone (first generation) or in combination with 1 (second generation) or 2 (third generation) costimulatory domains. Reprinted with permission.45

CAR structure, according to signaling domains. CAR molecules link scFv to intracellular signaling domains. The intracellular component includes the CD3ζ alone (first generation) or in combination with 1 (second generation) or 2 (third generation) costimulatory domains. Reprinted with permission.45 

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