Fig. 8.
Modulation of TRAIL sensitivity by NF-κB inhibitors.
(A) Effect of LLnL. TRAIL-sensitive or resistant cell lines were cultured for 42 hours in the absence or presence of rhsTRAIL (10 ng/mL for sensitive cell lines, 50 ng/mL for resistant cell lines) with or without LLnL (2.5 μM) pretreatment, and the 3H-thymidine uptake was determined for the last 6 hours. Data are represented as the mean ± SD of triplicate sample. (B) Effect of SN50. The TRAIL-sensitive cell line KOPM28 was cultured for 42 hours in the absence or presence of rhsTRAIL (10 ng/mL) with or without SN50 or SN50M (100 μg/mL) pretreatment, and the 3H-thymidine uptake was determined for the last 6 hours. Data are represented as the mean ± SD of triplicate sample.
