Soluble NRP-1 prolonged the survival of leukemic mice.

SCID mice were injected with M1 cells followed by intravenous injection of adenoviral vectors encoding for Fc-sNRP-1 (Ad.Fc-sNRP-1; ■), VEGF (Ad.VEGF; ●), and lacZ (Ad.LacZ; ▵), as described in the Figure 5legend. Mice (10 per group) were followed for 45 days after viral injection and a survival curve was generated. Mice injected with Ad.LacZ or Ad.VEGF had a mean survival of 28 days and mice injected with Ad.Fc-sNRP-1 had a mean survival of 35 days.