American Society of Hematology

Fig. 3.

$Fig. 3. Effect of PAR3 deficiency on bleeding time. / Tail bleeding was performed in a manner that provides a relatively strong hemostatic challenge (see “Materials and methods”). Offspring of PAR3 heterozygote crosses were studied. Shown is the fraction of tails still bleeding as a function of time after tail transection. Mice were genotyped after the bleeding times were measured. Genotypes and the number of mice of each genotype studied are indicated at right. The effect of genotype on bleeding time was significant by log-rank test (P < .0001), and the fraction of tails still bleeding at 10 minutes in thePar3−/− mouse group was different from that inPar3+/− and Par3+/+ mice by χ2 (P < .0001).$

Effect of PAR3 deficiency on bleeding time.

Tail bleeding was performed in a manner that provides a relatively strong hemostatic challenge (see “Materials and methods”). Offspring of PAR3 heterozygote crosses were studied. Shown is the fraction of tails still bleeding as a function of time after tail transection. Mice were genotyped after the bleeding times were measured. Genotypes and the number of mice of each genotype studied are indicated at right. The effect of genotype on bleeding time was significant by log-rank test (P < .0001), and the fraction of tails still bleeding at 10 minutes in thePar3^−/− mouse group was different from that inPar3^+/− and Par3^+/+ mice by χ² (P < .0001).

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