Structure and sequences of most commonly occurring Pax5 mRNA isoforms.

(A) Sequence of the exon junction observed in the Pax5 isoform from which exon 8 has been deleted. (B) Sequence of the exon junction observed in the Pax5 isoform from which exon 9 has been deleted. The base change shown in exon 8 was observed in P6. (C) Sequence of the exon junction observed in the Pax5 isoform from which exons 7-8 have been deleted. This isoform has been detected in the B cells of all healthy subjects. (D) Sequence of the exon junction observed in the Pax5 isoform from which exons 7-9 have been deleted. (E) Sequence of the isoform detected in the plasma cells of P17 that has an insert between exon 8 and exon 9.